TUDCA may have anti-metastatic effects on cancer

This study looked at how TUDCA, a bile acid often used for liver and gallbladder support, might affect breast cancer cell behavior in a lab setting. Researchers worked with an aggressive type of breast cancer cell (called MDA-MB-231) to see if TUDCA could make these cells less invasive (aka less likely to spread).

What they found was pretty fascinating: TUDCA reduced how much these cancer cells invaded surrounding tissue, even when the cells were under “stressful” conditions like low oxygen (which is common inside tumors).

They discovered that TUDCA works by calming down something called endoplasmic reticulum (ER) stress (the cell’s internal stress response system). When cells are under stress, they can start producing certain enzymes (MMP-7 and MMP-13) that help them break through healthy tissue... that’s part of how cancer spreads. TUDCA lowered the levels of those enzymes.

The key pathway involved here is called PERK, one of the main ER stress sensors. When this pathway is overactive, it can help cancer cells survive and invade. TUDCA seemed to dial that pathway down.

This study suggests that TUDCA may help slow or reduce cancer cell invasion by easing cellular stress and turning down the production of tissue-degrading enzymes. While it’s early research (done in a lab, not in humans), it points to a potential anti-metastatic effect of TUDCA and supports the idea that reducing cellular stress helps slow disease progression.

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 Read the study - https://pmc.ncbi.nlm.nih.gov/articles/PMC4998512/

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